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FLASH GENE
Symbol POLR3E contributors: - updated : 14-03-2005
HGNC name (RNA) III (DNA directed) polypeptide E (80kD)
HGNC id 30347
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 stomach   highly
Lymphoid/Immunelymph node   highly
 thymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Polr3e
ortholog to yeast C37 subunit
Homologene
FAMILY
CATEGORY enzyme , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters
  • involved in the regulation of cell cycle
  • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic , other
    signaling
  • tRNA metabolism
  • a component
  • component of the RNA polymerase III complex which consists of about 15 different subunits
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • POLR3D
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS