SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,vesicle
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text
| localized in synaptic vesicles |
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normally localizes to the endosomal-lysosomal compartment within morphologically altered neurons in neurodegenerative diseases, particularly in the brains of patients with Lewy bodies diseases |
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locate to membrane microdomains such as the neck of caveolae, microvilli/filopodia and intraluminal vesicles of multivesicular bodies |
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present in mitochondria, predominantly in the outer membrane |
basic FUNCTION
| serine/threonine kinase capable of activating the MAPK pathway in multiple cell lines in a kinase-independent fashion |
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potentiating neurotoxicity in a kinase-dependent manner (critical component of biochemical activity linking LRRK2 with neurodegeneration), and playing a central role in pathogenesis of several major neurodegenerative disorders associated with parkinsonism |
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potential role in the biogenesis and/or regulation of vesicular and membranous intracellular structures within the mammalian brain |
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involved in membrane trafficking system, and playing an important role in axon guidance during development |
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playing a potential role in the biogenesis and/or regulation of vesicular and membranous intracellular structures within the brain |
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regulates neurite maintenance and neuronal survival |
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GTPase domain of LRRK2 plays an important role in the regulation of kinase activity |
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first mammalian ROCO protein that is an authentic and functional GTPase and that may play a central role in integrating pathways involved in neuronal cell signaling and the pathogenesis of Parkinson disease |
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possible redundancy in the cerebral function between LRRK1 and LRRK2 |
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its kinase and GTPase activities may exhibit complex autoregulatory interdependence |
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involved in the endosomal–autophagic pathway and the recruitment to specific membrane microdomains (suggesting a novel function for this important Parkinson-related protein) |
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in conjunction with its interaction with RAB5B, plays an important role in synaptic function by modulating the endocytosis of synaptic vesicles |
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a role for LRRK2 in striatal dopamine transmission and the consequent motor function ( |
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a pivotal role in regulating striatal dopamin transmission and consequent control of motor function ( |
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plays an essential role in the regulation of protein homeostasis during aging ( |
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LRRK2 dimer possesses greater kinase activity than its more abundant monomeric counterpart |
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may impact on tau processing which subsequently leads to increased phosphorylation ( |
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involved in diverse cell biological functions, including translational control, mitogen-activated protein kinase, TNF/FASLG and Wnt signaling pathways |
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role for LRRK2 in kidney and lung physiology and further show that LRRK2 kinase function affects LRRK2 protein steady-state levels thereby altering putative scaffold/GTPase activity |
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regulates the cell protein translation machinery in diverse species and tissues |
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may be involved in vesicular trafficking by regulating membrane-bound proteins |
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its overexpression induces the formation of autophagosomes through a Ca2+/CaMKK/AMPK pathway (PMISD: 22012985) |
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regulates mitochondrial dynamics by increasing mitochondrial DNM1L through its direct interaction with DNM1L |
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increased mitochondrial recruitment of DNM1L |
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regulates mitochondrial dynamics through the fission/fusion pathway in neurons |
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LRRK2 participates in canonical Wnt signaling as a scaffold |
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importance of LRRK2, but not LRRK1, catalytic activity for Wnt signaling activation |
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LRRK2 acts as an upstream kinase in the MAP3K5 pathway and plays an important role in the pathogenesis of Parkinson disease |
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LRRK2 and RAB29 act coordinately in an ordered genetic pathway to regulate axonal elongation |
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converging roles of two PD genes TMEM230 and LRRK2 on RAB8A function, suggesting that retromer and secretory dysfunction play an important role in Parkinson disease (PD) pathogenesis |
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new function of LRRK2 mediated by RAB8A phosphorylation and related to various centrosomal defects |
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small Rab GTPase involved in vesicular trafficking |
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stress-responsive machinery composed of RAB29, LRRK2, phosphorylated RAB8/RAB10, and their downstream effectors implicated in the maintenance of lysosomal homeostasis |
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is a multidomain protein involved in many cellular functions, including cell proliferation, survival regulation of neural stem cells (NSCs), and neurogenesis |
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LRRK2 is involved in the regulation of nigrostriatal system development |
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plays an important role in actin and microtubule dynamics |