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FLASH GENE
Symbol D2HGDH contributors: mct - updated : 23-01-2015
HGNC name D-2-hydroxyglutarate dehydrogenase
HGNC id 28358
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrinepancreas    
Nervousbrain    
Reproductivefemale systemovary   
 male systemprostate   
Skin/Tegumentskin    
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
FAD domain
HOMOLOGY
interspecies homolog to murine D2hgdh
Homologene
FAMILY FAD-binding oxidoreductase/transferase type 4 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
basic FUNCTION
  • converting D-2-hydroxyglutarate into 2-ketoglutarate
  • D-2-hydroxyglutarate dehydrogenase, which converts D-2HG to 2-oxoglutarate and decreases the level of D-2-hydroxyglutaric acid (D-2HG)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism organic acid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) D2HA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS