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FLASH GENE
Symbol SRSF7 contributors: mct/npt - updated : 17/11/2008
HGNC name serine/arginine-rich splicing factor 7, 35kDa
HGNC id 10789
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 salivary gland   highly
Endocrineadrenal gland   moderately
Lymphoid/Immunethymus   moderately
Nervousbrain    
Reproductivefemale systemuterus  moderately
Respiratorylung    
Urinarybladder   highly
 kidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text differentially, in fetal tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RRM (RNA recognition motif) domain
  • a CCHC-type zinc knuckle motif
  • a C terminal RS domain
  • HOMOLOGY
    interspecies homolog to murine Sfrs7 (98.3 pc)
    Homologene
    FAMILY
  • arginine/serine-rich 10 (SR family)
  • splicing factor SR family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • required for pre-mRNA splicing
  • mediating protein-protein interaction within the intron during spliceosome assembly
  • independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing
  • playing a key role in regulation of exon 10 splicing and imply a pathogenic role in neurodegenerative diseases
  • play a role in mRNA export, in particular of histone mRNAs (Hargous 2006)
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the E commitnent complex in the spliceosome assembly pattern
  • INTERACTION
    DNA
    RNA binding
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with CCNL2 and CPSF6
  • cell & other
    REGULATION
    Other extensively phosphorylated on serine residues in the RS domain
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS