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FLASH GENE
Symbol ISY1 contributors: mct - updated : 20-02-2013
HGNC name ISY1 splicing factor homolog (S. cerevisiae)
HGNC id 29201
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunespleen   moderately
Nervousbraindiencephalonamygdala moderately
 brainhindbraincerebellum moderately
Reproductivefemale systemovary  highly
Respiratorylung   highly
Skin/Tegumentskin   highly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ISY1 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • implicated in the first catalytic step of splicing and splicing fidelity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the ATPase DHX38 to regulate the fidelity of pre-mRNA splicing
  • multiple functions for SRRM2 in the splicing process, including an important role in the activation of splicing in association with ISY1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS