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FLASH GENE

Symbol

ZBTB4

contributors: SGE - updated : 24-08-2009

HGNC name	zinc finger and BTB domain containing 4
HGNC id	23847

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine parathyroid       highly Nervous brain       highly Respiratory lung         Urinary kidney         Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain, liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one BTB/POZ domain, POZ domain
	6 C2H2-type zinc fingers
	Kaiso-like zinc fingers

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies	homolog to rattus Zbtb4 (88.6pc)
	homolog to murine Zbtb4 (89.2pc)

intraspecies

homolog to ZBTB33

Homologene

FAMILY

Kaiso-like proteins family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be involved in transcriptional regulation
	able to repress transcription in a methyl-dependent manner, yet their tissue-specific expression pattern suggests nonoverlapping functions
	represses transcription of CDKN1A and controls the cellular response to TP53 activation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

homodimer or heterodimerizing with ZBTB38 (Filion 2006)

INTERACTION

DNA	bind methylated DNA

RNA

small molecule	metal binding,
	ions Zn2+

protein	bind methylated CGCGs through its three Kruppel-like C2H2 zinc fingers
	associates with the Sin3/histone deacetylase co-repressor and represses expression of CDKN1A as part of a heterodimeric complex with ZBTB17
	shares with ZBTB33 the ability to bind both methylated DNA and the KBS (Kaiso binding site)
	with CDKN1A may have critical oncogenic functions independent of the TP3 status of a cell

cell & other

REGULATION

Other

phosphorylated by HIPK2 and down-regulated (Yamada 2009)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in advanced stages of multiple tumours

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS