basic FUNCTION
| C4HC3 RING finger-containing ubiquitin ligase, ER degradation substrate itself, promoting its own degradation in a RING finger- and proteasome-dependent manner |
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mediates degradation of type 2 iodothyronine deiodinase |
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regulator of cholesterol biosynthesis, owing to its ability to promote degradation of the rate-limiting enzymes 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR) and squalene epoxidase (SQLE) |
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MARCHF6-dependent mechanism to direct cellular cholesterol accretion that relies on uncoupling of cholesterol synthesis from lipoprotein uptake |
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MARCHF6 and RNF139 facilitate the quality control of cytosolic and tail-anchored proteins |
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is a polytopic enzyme bound to the membranes of the endoplasmic reticulum |
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MARCHF6 is the first example of an E3 ubiquitin ligase which targets multiple steps in a biochemical pathway |