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FLASH GENE
Symbol LZTS3 contributors: npt/mct - updated : 26-10-2018
HGNC name leucine zipper tumor suppressor family member 3
HGNC id 30139
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex lowly
 brain   predominantly Homo sapiens
 nervecranial nerveoptic nerve lowly
Urinarykidney   predominantly Homo sapiens
Visualeyeretinafovea lowly
 eyeretinamacula lowly
 eyelens  lowly
 eyeanterior segment  lowly
 eyeuveachoroid lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryolfactory  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a unique PDZ domain
  • HOMOLOGY
    interspecies homolog to murine Prosapip1
    homolog to rattus Prosapip1
    intraspecies homolog to human KIAA0341
    homolog to significant sequence homology with the PSD protein LZTS1
    Homologene
    FAMILY
  • ProSAPs/Shanks family
  • leucine zipper tumor suppressor (LZTS) protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text co-localizes with ProSAP2/Shank3 in excitatory spines and synapses
    basic FUNCTION
  • have a major scaffolding function for components of the postsynaptic density (PSD) of excitatory brain synapses
  • is indeed involved in promoting the maturation of dendritic spines—most probably via regulating SPAR levels at the PSD
  • fulfill specific molecular functions at the PSD to guarantee the proper maturation of excitatory spine synapses
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text cell growth and/or maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind and recruit SIPA1L1 to synapses with a central coiled-coil region that harbors a leucine zipper motif
  • interaction partner of the well-known PSD protein SHANK3 and SPAR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS