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FLASH GENE
Symbol MAGEH1 contributors: mct - updated : 07-05-2020
HGNC name melanoma antigen family H, 1
HGNC id 24092
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselaorta   
Nervousbrainforebraincerebral lobefrontal lobe 
 brainhindbraincerebellumcerebellar cortex 
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney     Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Membraneserous membranepericardium  
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one MAGE domain
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • may be involved in apoptosis
  • MAGEH1 associates with the intracellular domain of the NGFR and regulates the cell cycle
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NDN and MAGEH1, are interactors for the intracellular domain of NGFR and the interaction is enhanced by ligand stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma (HCC) tumor tissues compared with adjacent normal liver tissues and significantly correlated with poor prognosis in HCC patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • negative expression of MAGEH1 protein serves as a potential predictive marker for the effectiveness of gemcitabine therapy in biliary tract carcinoma (BTC)
  • may serve as a potential biomarker and a new prognostic factor for hepatocellular carcinoma (HCC)
  • aberrant expression patterns of MAGEH1 in teratocarcinoma cells can be considered as specific teratocarcinoma biomarkers promoted the malignant phenotype
  • Therapy target
    ANIMAL & CELL MODELS