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FLASH GENE
Symbol YWHAB contributors: mct/ - updated : 26-06-2015
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HGNC id 12849
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 salivary gland   highly
Endocrineparathyroid   moderately
 thyroid   moderately
Hearing/Equilibriumear   predominantly
Lymphoid/Immunetonsils   highly
Nervousnervespinal nerve   
Reproductivefemale systembreastmammary gland moderately
Skin/Tegumentskin   highly
Urinarybladder   highly
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
Connectivebone  moderately
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
interspecies homolog to murine Ywhab
ortholog to rattus Ywhab (98.4pc)
intraspecies homolog to ywhaz
Homologene
FAMILY
  • 14.3.3 family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text perinuclear region
    basic FUNCTION
  • inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
  • multifunctional regulator
  • activating protein kinase C, multifunctional regulator of the cell signaling processes mediated by both kinases
  • enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), regulates the pace of the circadian clock
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
  • 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs and molecules such as Raf, BAD and Cbl
  • AKIRIN2-YWHAB complex could act as a transcriptional silencer, and MAPK1 was one of the target genes of the AKIRIN2-YWHAB complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38 MAP kinase
  • ITGB1 for regulation of integrin-mediated cell adhesion and signaling events
  • the TSC1-TSC2 complex and negatively regulate the function of the TSC proteins
  • SSH1
  • interaction with ATXN1, YWHAE, YWHAH, YWHAZ mediated by AKT1 to modulate the neurotoxicity of SCA1
  • interacting with AKIRIN2
  • phosphorylation-dependent interaction between YWHAB and SPTAN1 acts as a switch between positive and negative regulation of neurite outgrowth stimulated by NCAM
  • interacts with DACT1 (YWHAB binding attenuates the ability of hDpr1 to promote Dishevelled (Dvl) degradation, thus enhancing Wnt signaling)
  • YWHAB binding to phosphorylated CFTR augments its biogenesis by reducing retrograde retrieval of CFTR to the endoplasmic reticulum
  • YWHAB is absolutely required for KCNK3 internalization, a role heretofore not described for a 14-3-3 protein
  • interactors of GCGR, LDLR and TMED2, significantly enhanced glucagon-stimulated glucose production, while YWHAB inhibited glucose production
  • interaction of DAPK2 with ACTN1 was localized at the plasma membrane, resulting in massive membrane blebbing and reduced cellular motility, whereas the interaction of DAPK2 with YWHAB was localized to the cytoplasm, with no impact on blebbing, motility, or viability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • has the potential to be used as a diagnostic and prognostic biomarker in gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS