motifs/domains
| a low density lipoprotein receptor cysteine-rich motif, class A (LDL-A) module at the N terminus, influencing receptor maturation, cell surface expression, and relaxin-activated signal transduction, and essential for receptor activation |
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10 LRR domains |
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six putative Asn-linked glycosylation sites in the ectodomain at positions Asn-14, Asn-105, Asn-242, Asn-250, Asn-303, and Asn-346 (Yan 2008) |
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seven transmembrane region |
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a unique C-terminal tail with LDLa module and a phosphorylation site, important in agonist-stimulated receptor internalization (Kern 2009), and four acidic AAs in the C-terminal region of the RXFP1 LDLa with the ligand binding domain (LB2) modules whose ligation of a Ca2+ is crucial for maintaining structural integrity |