Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MED19 contributors: mct - updated : 11-04-2012
HGNC name mediator of RNA polymerase II transcription, subunit 19 homolog (yeast)
HGNC id 29600
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunetonsils   highly
Nervousbrainhindbrainmedulla oblongata  
Urinarykidneytubuleconvoluted tubuleproximal tubule 
Visualeyelens   
 eyeanterior segmentiris  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Connectivebone  highly
Connectivebone  highly
Epithelialsensoryolfactory  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators
  • novel proliferation regulator that promotes growth of lung cancer cells
  • plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas
  • serves as a novel proliferation regulator that promotes growth of prostate cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MED19 and MED26 subunits in Mediator are direct physical and synergistic functional targets of REST
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    may serve as a new molecular target for lung cancer therapy
    ANIMAL & CELL MODELS