Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UBE2T contributors: mct/npt/pgu - updated : 28-08-2016
HGNC name ubiquitin-conjugating enzyme E2T (putative)
HGNC id 25009
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousbrain    
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ubiquitin-conjugating enzyme family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • having ubiquitin-protein ligase activity
  • ubiquitin-conjugating enzyme (E2) in the Fanconi anemia pathway and has a self-inactivation mechanism that could be important for negative regulation of the Fanconi anemia pathway
  • with Fanconi anemia (FA) nuclear core complex are required for the S phase and DNA damage-restricted monoubiquitination of FANCD2, but FANCD2 monoubiquitination is not regulated by multiprotein complex assembly but by the formation of an active E2/E3 holoenzyme on chromatin
  • involved in the monoubiquitination reaction of FANCD2 with the FANCL protein
  • ubiquitin ligase required in the Fanconi anemia (FA) DNA repair pathway
  • UBE2T and FANCM are functionally linked to nucleotide excision repair
  • might have a function outside the Fanconi anemia pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to FANCL, the ubiquitin ligase subunit of the Fanconi anemia core complex, and is required for the mono-ubiquitination of FANCD2
  • binding of FANCL with its partners, UBE2T, FANCD2, and FANCI
  • is the E2 ubiquitin-conjugating enzyme for FANCD2 and FANCI
  • is the ubiquitin-conjugating enzyme for the FA-BRCA pathway
  • cell & other
    REGULATION
    Other reduced UBE2T mRNA expression is HIF independent and was not due to changes in mRNA or protein stability, but rather reflected reduced promoter activity
    ASSOCIATED DISORDERS
    corresponding disease(s) FANCT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with early and advanced stages, lymph nodes, distant metastases and risk factors such as H. pylori in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS