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FLASH GENE
Symbol HACD3 contributors: mct - updated : 03-02-2020
HGNC name 3-hydroxyacyl-CoA dehydratase 3
HGNC id 24175
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus    
 intestinesmall intestine   
Endocrineadrenal gland    
 neuroendocrinepituitary   
 pancreas    
Nervousbrain    
Reproductivemale systemtestis   
 male systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to murine Ptplad1 (90.3pc)
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,nuclear envelope
basic FUNCTION
  • potentiating different effects of the small GTPase RAC1, such as c-Jun N-terminal kinase activation
  • transcriptional activity of nuclear factor kappaB (NF-kappaB
  • overexpressed HACD3 exhibited weak activity in saturated and monounsaturated fatty acids (FAs) elongation pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with RAC1 (component of RAC1-signaling pathways leading to the modulation of gene expression)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSP90AA1-dependent chaperone pathway incorporating HACD3 is involved in protein folding in the membranous web for the circumvention of the UPR and that it facilitates HCV replication
  • ATIC, which is a rate-limiting enzyme in the de novo purine biosynthesis pathway, and PTPLAD1 are associated with insulin receptor (INSR) internalization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS