Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MGAT4C contributors: mct - updated : 20-02-2013
HGNC name mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
HGNC id 30871
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrainforebraincerebral lobefrontal lobe 
 braindiencephalonhypothalamus  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly hydrophobic N-terminal region, which may be a transmembrane domain
  • a hydrophilic region, which may be a stem region
  • lacking the proline-rich stem sequence found in other N-acetylglucosaminyltransferases
  • HOMOLOGY
    Homologene
    FAMILY
  • glycosyltransferase 54 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • glycosyltransferase involved in catalyzing GlcNAc beta1–4 linkage to the core mannose residues of N-glycans for tri- or tetraantennary N-glycan structures
  • predicted glycosyltransferase, implicated in PROM1 N-glycosylation
  • may have potentially an important role in certain cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • positive regulator of cell surface PROM1 expression
  • PROM1 acts as an MGAT4C substrate for complex N-glycan processing, which contributes to cell surface PROM1 recognition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS