Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HELB contributors: mct - updated : 25-08-2016
HGNC name helicase (DNA) B
HGNC id 17196
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   lowly
Lymphoid/Immunespleen   lowly
 thymus   highly
Nervousbraindiencephalonhypothalamus  
Reproductivemale systemtestis  highly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryolfactory  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • playing an essential role for S phase entry
  • operates primarily during G1 to process endogenous DNA damage before the G1/S transition, and it is largely sequestered in the cytoplasm during S/G2
  • replication stress-induced recruitment of HELB to chromatin is independent of checkpoint signaling but correlates with the level of replication protein A (RPA) recruited to chromatin
  • facilitates cellular recovery from replication stress and promotes homologous recombination
  • role of HELB in the beginning of the DNA synthesis
  • acts independently of TP53BP1 and is exported from the nucleus as cells approach S phase, concomitant with the upregulation of DNA end resection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA RNA binding
    small molecule
    protein
  • HELB interacts directly with two initiation factors TOPBP1 and CDC45 (both, the N-terminus and helicase domain of HELB bind to the N-terminus of CDC45)
  • regulates DNA replication through association with human DNA polymerase alpha-primase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS