basic FUNCTION
| initiating the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction |
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seems to be highly expressed in cells with high proliferative potential (Hildrestrand 2009) |
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its function might be required in proliferating cells to remove lethal and mutagenic lesions from the genome (Liu 2010) |
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exercises a highly specialized function through accurate molecular repair of DNA in rapidly proliferating cells |
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DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells |
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NEIL3-dependent repair of oxidative DNA damage in neural stem/progenitor cells is required for maintenance of adult neurogenesis to counteract the age-associated deterioration of cognitive performance |
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functional DNA glycosylase having a different substrate specificity and unusual structural features compared with other Fpg/Nei homologs |
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is one of the four DNA glycosylases found to recognize and remove hydantoins in the first step of base excision repair (BER) pathway |
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involvement in removal of replication blocks in proliferating cells |
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DNA glycosylase of the base excision repair pathway that protects cells from oxidative DNA damage by excising a broad spectrum of cytotoxic and mutagenic base lesions |
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exhibits an unusual preference for DNA with single-stranded regions |
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role for NEIL3 and NEIL1 is to repair DNA base damages in telomeres and NEIL3 and NEIL1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA |