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FLASH GENE
Symbol EXOSC1 contributors: mct - updated : 08-07-2013
HGNC name exosome component 1
HGNC id 17286
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Skin/Tegumentcornified cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one S1 RNA-binding motif
mono polymer heteromer , tetramer
HOMOLOGY
interspecies ortholog to S. cerevisiae CSL4
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleolus
basic FUNCTION
  • core component of the exosome, required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the exosome, a complex of 3'-5'exoribonucleases
  • association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46
  • trimer of EXOSC1 or EXOSC2 subunits forms a multidomain macromolecular interaction surface on the RNase-PH domain ring with central S1 domains and peripheral KH and zinc-ribbon domains
  • INTERACTION
    DNA
    RNA RNA binding
    small molecule
    protein
  • N- and C-terminal regions required for interaction with EXOSC5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS