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FLASH GENE
Symbol GSS contributors: mct - updated : 05-03-2011
HGNC name glutathione synthetase
HGNC id 4624
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon highly
 mouth   highly
Nervousbrain    
Reproductivefemale systemuteruscervix highly
 male systemprostate   
Visualeyelens   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glycine residues in the G-loop maintaining loop flexibility essential for ligand binding and active site closure
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY eukaryotic GSH synthase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • essential tripeptide antioxidant, that protects against reactive oxygen species and participates in metabolism of drugs and carcinogens
  • involved in glutathione biosynthesis second step
  • plays an important role in defending the cell against reactive oxygen species
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    sulfur metabolism, glutathione biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by NFE2L2
    ASSOCIATED DISORDERS
    corresponding disease(s) GSS , GSDE
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS