basic FUNCTION
| mediator of the well-established antagonism of RAC1 by RHOA that suppresses leading edge protrusion and promotes cell retraction to achieve cellular polarity |
|
plays a role in protecting cells against force-induced apoptosis, and this function is mediated by FLNA |
|
Rac GTPase-activating protein (GAP), that is a mediator of RHO/ROCK-dependent amoeboid movement of carcinoma cells |
|
ARHGAP24 and its close relatives are key regulators that promote the reciprocal inhibitory relationship between RHOA and RAC1 in cell shape changes and the mesenchymal-amoeboid transition in tumour cells |
|
may function as a mediator of the regulation of RAC1 by ARF6 |