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FLASH GENE
Symbol CHTF8 contributors: mct/npt - updated : 09-04-2018
HGNC name CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
HGNC id 24353
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Nervousbrainbasal nucleicaudate nucleus  
 brainbasal nucleicorpus callosum  
Reproductivemale systemtestis  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to zebrafish Dr.24240
homolog to xenopus Xl.105691
Homologene
FAMILY
  • CTF8 family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be implicated in tumorigenesis of kidney and prostate
  • involved in establishment of sister chromatid cohesion
  • CHTF8-RFC1 has additional important functions in preserving genome stability, besides its role in sister chromatid cohesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • C-terminal 23-AA stretch of CHTF18 was necessary for the trimeric association of complex CHTF18, DSCC1, and CHTF8 and was required for the stable interaction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CHTF18-DSCC1-CHTF8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA (Bermudez 2003)
  • CHTF18-RFC1 clamp loader contains a unique module in which the DSCC1-CHTF8 complex is bound to the C terminus of CHTF18 (the CHTF18-DSCC1-CHTF8 module)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    prostate and renal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS