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FLASH GENE
Symbol PLXNB1 contributors: mct - updated : 14-01-2016
HGNC name plexin B1
HGNC id 9103
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinelarge intestinecolon highly
Endocrinethyroid   highly
Nervousbrain   highly
 nerve   highly
Reproductivemale systemprostate  highly
Respiratoryrespiratory tractlarynx  predominantly
 respiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
Nervousneuron
cell lineage hematopoietic cells
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Sema domain
  • three IPT/TIG domains
  • a RHO binding domain (B1RBD)
  • conjugated GlycoP , PhosphoP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Plxnb1 (87 pc)
    homolog to murine Plxnb1 (87.3 pc)
    intraspecies homolog to the hepatocyte growth factor receptor family
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • single-pass type I membrane protein
  • basic FUNCTION
  • acting as a receptor for SEMA4D
  • playing a role in RHOA activation and subsequent changes of the actin cytoskeleton
  • playing a role in axon guidance, invasive growth and cell migration
  • promoting binding of cytoplasmic ligands by the interaction with SEMA4D
  • having a role in prostate cancer progression
  • SEMA4D/PLXNB1 promotes the dephosphorylation and activation of PTEN through the RRas GAP activity, inducing growth cone collapse
  • SEMA4D/PLXNB1-mediated NFKB1 activation and IL8 production is critical in the generation a pro-angiogenic phenotype in endothelial cells
  • role for PPLXNB1 in maintenance of melanocyte survival and proliferation in the skin, suggesting that SEMA4D and PLXNB1 act cooperatively with HGF and MET to regulate MET-dependent effects in human melanocytes
  • PLXNB1 and SEMA4D cooperate to promote perineural invasion in a RHOA/ROK-dependent manner
  • SEMA4D receptor PXNBB1 induces repulsion in axon and dendrites by functioning as a GTPase-activating protein (GAP) for RRAS and MRAS, respectively
  • CELLULAR PROCESS cell life, differentiation
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    text
  • positive regulation of axonogenesis
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • monomer
  • heterodimer with PLXNB2 after proteolytic processing
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to the GTP binding activated RAC1
  • binding to ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, NRP1 and NRP2
  • binding to PLXNA1
  • interacting with SEMA4D (its ligand)
  • SEMA4D, enhances tumor cell motility through binding its receptor, PLXNB1, in pancreatic cancer
  • SEMA4D/PLXNB1-mediated MRas GAP activity regulates actin-based dendrite remodeling through RAPH1
  • binds in a GTP-dependent manner to RAC1, RAC2, RAC3, RND1, RND2, RND3, and RHOD
  • SEMA4D act through its receptor PLXNB1 to regulate axon growth cone guidance, lymphocyte activation, and bone density
  • SEMA3C drives activation of multiple RTKs including EGFR, ERBB2, and MET in a cognate ligand-independent manner via PLXNB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in localized and metastatic prostate carcinoma
    tumoral     --over  
    in prostate carcinoma
    tumoral     --over  
    significantly higher in serous ovarian carcinomas than in normal ovaries
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    might be a useful biomarker and/or a novel therapeutic target in ovarian carcinoma
    ANIMAL & CELL MODELS