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FLASH GENE
Symbol FBXO42 contributors: mct/npt - updated : 08-09-2009
HGNC name F-box protein 42
HGNC id 29249
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   moderately
Endocrinepancreas   moderately
Nervousbraindiencephalonamygdala lowly
 brainlimbic systemhippocampus lowly
Reproductivemale systemtestis   
Respiratorylung   lowly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an F-box motif in the N terminus
  • a Kelch domain downstream of the F-box
  • four Kelch repeats
  • a CHORD domain
  • the TPR-like domain
  • the CASH domain
  • the SPRY domain (Sun 2009)
  • HOMOLOGY
    interspecies ortholog to murine Fbxo42
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex
  • promotes ubiquitination and degradation of TP53 (Sun 2009)
  • promotes TP53 turnover through assembly of an SCF complex, revealing a pathway for the control of TP53 degradation and providing a link between the SCF complex and TP53 regulation (Sun 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with SKP1, CUL1, and RBX1, the components of the SCF Complex, and may thus function via assembly of an SCF complex (Sun 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS