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FLASH GENE
Symbol SLC15A2 contributors: mct - updated : 24-05-2008
HGNC name solute carrier family 15 (H+/peptide transporter), member 2
HGNC id 10921
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratoryrespiratory tracttrachea  highly
Urinarykidney   highly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve TM domains
  • a long hydrophilic segment between TM domain 9 and 10
  • HOMOLOGY
    Homologene
    FAMILY PTR2/POT transporter family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating the cellular uptake of di- and tripeptides as well as a variety of drug molecules
  • mediates the high-affinity low-capacity transport of small peptides as well as various oral peptide-like drugs in the kidney
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with PDZK1 (plays a physiologically important role in both oligopeptide handling as well as peptide-like drug transport in the kidney)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS