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FLASH GENE
Symbol FRMD3 contributors: mct/npt - updated : 15-05-2019
HGNC name FERM domain containing 3
HGNC id 24125
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Respiratorylung   highly
Urinarykidney   highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroid
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one FERM domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein 4.1 superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • critical growth regulator in the pathogenesis of meningiomas
  • playing a key role in erythrocytes in regulating the physical properties of mechanical stability and deformability in membranes by stabilizing the spectrin-actin interaction
  • putative tumour suppressor gene suggesting an important role in the origin and progression of lung cancer (Haase 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    in primary non-small cell lung carcinoma (Haase 2007)
    Susceptibility
  • susceptibility to diabetic nephropathy in type 1 diabetes
  • Variant & Polymorphism other
  • strong association was identified at the FRMD3 locus with susceptibility to diabetic nephropathy in type 1 diabetes
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS