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FLASH GENE
Symbol KCNAB1 contributors: mct - updated : 24-06-2014
HGNC name potassium voltage-gated channel, shaker-related subfamily, beta member 1
HGNC id 6228
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouthtongue  highly
Lymphoid/Immunethymus   highly
Nervousbrainforebraincerebral cortex   Homo sapiens
 brainhindbraincerebellum predominantly
 nerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer , complex
HOMOLOGY
interspecies homolog to Drosophila shaker-related subfamily
intraspecies homolog to NAD(P)H dependent oxidoreductases
Homologene
FAMILY shaker potassium channel beta subunit family
CATEGORY transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • modulating the amplitude of K+ currents
  • play a critical role in regulating arterial tone by modulating the membrane potential of vascular smooth muscle cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ion transport
    PATHWAY
    metabolism
    signaling
    a component
  • channel constituent (coassembly in the endoplasmic reticulum with the channel forming alpha subunits)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating by its N terminus with beta subunits
  • functional coupling between the KCNA1 channel and aldoketoreductase KCNAB1
  • cell & other
    REGULATION
    repressed by BMP2 that significantly (>2-fold) downregulated mRNA expression of KCNAB1 9)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to lateral temporal epilepsy (LTE)
    Variant & Polymorphism SNP SNP (rs992353) located near the 3 prime end of KCNAB1 slightly associated with LTE
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS