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FLASH GENE
Symbol NEXN contributors: mct - updated : 16-12-2009
HGNC name nexilin (F actin binding protein)
HGNC id 29557
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Skin/Tegumentskinscalp    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminally located actin-binding domains (ABD)
  • one IQ domain
  • one myosin-like globular head domain
  • a coiled-coil domain (CC)
  • a C-terminal immunoglobulin superfamily class
    • HOMOLOGY
    interspecies homolog to murine Nexn
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • F-actin-binding protein at cell-matrix adherens junctions
    • basic FUNCTION
  • may regulate the formations of stress fibers, focal adhesion and its signaling complex, and even participate in the signal transduction in focal adhesions
  • F-actin associated protein that mediates cell motility
  • Z-disk protein, playing an unique role in protecting Z-disks from mechanical trauma
  • crucial protein that functions to protect cardiac Z-discs from forces generated within the sarcomere
  • has a unique role in stabilizing cardiac Z-discs and is essential for maintaining Z-disc integrity against the extreme forces generated during muscle contraction
    • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • F-actin associated protein
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1CC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS