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FLASH GENE
Symbol PHF19 contributors: mct - updated : 21-09-2013
HGNC name PHD finger protein 19
HGNC id 24566
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 neuroendocrinepituitary  highly
Lymphoid/Immunelymph node   highly
 thymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Tudor domains that selectively bind to histone H3K36me3
  • two PHD-type zinc fingers, and specific PHD2 domain, which is better conserved than PHD1 in the PCL family, is also involved in the EZH2 interaction and implicated in the self-association of PCL3L
  • the first PHD domains do not exhibit histone H3K4 binding ability, nor do they affect the Tudor domain binding to histones
  • HOMOLOGY
    interspecies homolog to murine 3321402G02Rik
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in DNA-dependent regulation of transcription
  • common function of PHF1, MTF2 and PHF19 is recruitment of the PRC2 complex to its target genes for histone methylation, Hox gene silencing and ESC (Extra Sex Combs) self-renewal
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • both PCL3 isoforms are physically associated with EZH2, but in different complexes
  • EHMT2 orchestrates PHF19 and KDM7A to promote histone H3K27 methylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS