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FLASH GENE
Symbol ADH7 contributors: mct - updated : 26-02-2008
HGNC name alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
HGNC id 256
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  predominantly
 stomach    
Respiratorylung   highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)  
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivegastric
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine Adh7
Homologene
FAMILY
  • zinc-containing alcohol dehydrogenase family
  • class-IV subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • alcohol dehydrogenase (class IV) sigma polypeptide most active on retinol dehydrogenase, zinc dependent
  • participating in the synthesis of retinoic acid
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism vitamin
    signaling
    synthesis of retinoic acid
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ (2 ions per subunit)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to variation of alcohol absorption
    Variant & Polymorphism SNP a recombinational hotspot within intron 7 influencing metabolism of alcohol before its absorption into the blood
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS