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FLASH GENE
Symbol PTPN13 contributors: mct - updated : 06-10-2010
HGNC name protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
HGNC id 9646
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
 pancreas   moderately
Hearing/Equilibriumearinnercochlea highly
Urinarykidney   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • the GLGF repeat and a leucine zipper domain
  • a membrane binding region, homologous to that found in cytoskeleton associated proteins, ezrin/moesin/radixin-like (ERM) family member
  • five PDZ/DHR domains
  • HOMOLOGY
    interspecies homolog to murine Ptpn13
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • tyrosine phosphatase, non receptor, responding and participating in reorganization of membrane-cytoplasmic interactions
  • in association with PARG1, may function as a negative regulator of Rho signaling
  • plays a counteracting role in regulating TRIP6 function in lysophosphatidic acid (LPA)-induced cell migration
  • plays a wider role in modulating cell motility through dephosphorylation of other substrates involved in cell adhesion and migration
  • specifically dephosphorylates insulin receptor substrate-1 (IRS1), having a crucial role in IRS1 dephosphorylation
  • direct positive role of the putative tumor suppressor gene PTPN13 on apoptosis
  • IRF8-induced PTPN13 repression occurred in granulocyte/monocyte progenitor cells, and this activity increased during myeloid differentiation
  • PTPN13 is an IRF8 target gene
  • inhibits ERBB2 activity by dephosphorylating the signal domain of ERBB2 and plays a role in attenuating invasiveness and metastasis of ERBB2 overactive tumors
  • important regulatory element of breast tumor aggressiveness and sensitivity to treatments such as antiestrogens and antiaromatase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRKCL2 for regulation of the action cytoskeleton
  • the four most C-terminal amino acid residue of PARG1 interacts specifically with the fourth PDZ domain of PTNP13
  • transcriptional target of EWS-FLI1
  • target gene of IRF8 (interacted with a cis element in the proximal PTPN13 promoter and repressed transcription)
  • interaction with FAS results in FAS dephosphorylation and inhibition of FAS-induced apoptosis
  • interacting with PDLIM4 and SRC (PDLIM4 suppresses SRC activation through interacting with SRC and PTPN13, allowing PTPN13-dependent dephosphorylation of SRC at the activation loop)
  • PTPN13 is an IRF8 target (repression of PTPN13 by IRF8 requires cooperation with ETV6 and histone deacetylase 3)
  • VCP regulation by PTPN13 might be important for tumorigenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Ewing's Sarcoma family tumors, with metastasis
    tumoral somatic mutation      
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS