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FLASH GENE
Symbol YTHDC1 contributors: npt - updated : 10-08-2004
HGNC name YTH domain containing 1
HGNC id 30626
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivestomach    
Nervousbrain    
Reproductivefemale systemuterus   
 male systemprostate   
Urinarybladder    
 kidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • YTH domain
  • HOMOLOGY
    interspecies ortholog to rat spicing factor Yt521
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • in YT bodies when is non-phosphorylated and soluble;
  • after phosphorylation is associated with an insoluble nuclear structure in the nucleoplasm
  • basic FUNCTION
  • playing a role in the changement of splice site selection, in a concentration -dependent manner (abolished ability wehn is in an insoluble nuclear form)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tyrosine phosphorylated by ABL1 in the nucleus
  • cell & other
    REGULATION
    inhibited by emerin
    Other regulated by tyrosine phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS