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FLASH GENE
Symbol RNASEH2B contributors: mct - updated : 17-01-2014
HGNC name ribonuclease H2, subunit B
HGNC id 25671
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunespleen    
 thymus   highly
Nervousbrain    
Reproductivemale systemprostate   
 male systemtestis   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PIP-box and confers PCNA binding to RNase H2
  • mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • RNase H2 subunit B family
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • beta subunit of the ribonuclease H2 enzyme complex which cleaves ribonucleotides from RNA: DNA duplexes
  • may function to degrade RNA/DNA hybrids during cell death to avoid nucleic acid-mediated immune activation
  • ribonuclease H enzymes that specifically recognize RNA/DNA hybrids and hydrolyze the ribonucleotide-containing polynucleotide strand
  • SAMHD1, TREX1, and RNase H2 participate in a cellular nucleic acid metabolic pathway that overlaps the interferon-mediated innate antiviral and inflammatory responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component RNase H2 is a heterotrimeric complex of the RNase H2A, RNase H2B, and RNase H2C proteins that are all required for proper function and activity
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNASEH2A interfaces mostly with the RNase H2C subunit that is intricately interwoven with the RNase H2B subunit
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AGS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    induce a CGAS/TMEM173-dependent innate immune response
    constitutional       loss of function
    are also associated with systemic lupus erythematosus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS