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FLASH GENE
Symbol PLIN3 contributors: mct - updated : 23-06-2010
HGNC name perilipin 3
HGNC id 16893
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Lymphoid/Immunelymph node    
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to rattus M6prbp1 (74.60 pc)
homolog to murine M6prbp1 (75.52 pc)
Homologene
FAMILY
  • perilipin family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • resides in a late endosome microdomain together with mannose 6-phosphate receptors (MPRs) and RAB9A
  • occurs in the cytosol and on endosomal membranes, and shuttles between these two compartment
  • basic FUNCTION
  • lipid droplet protein that regulate cellular neutral lipid stores
  • required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network
  • delivering lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex
  • involved in lipid droplets
  • cytosolic protein that is essential for the transport of mannose 6-phosphate receptors (MPRs) from endosomes to the trans-Golgi
  • has apolipoprotein-like properties and reorganizes liposomes into small lipid discs
  • may act as a carrier protein for free fatty acids and in this way participates in conversion of macrophages into foam cells
  • can reorganize liposomes into small lipid discs, and it is recruited to lipid droplets
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • can bind to mitochondria in oxidative stress, and inhibit mitochondria mediated cell death by protecting mitochondrial membrane integrity
  • protein
  • M6PR
  • IGF2R
  • interacting with RAB9A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical tumors, with correlation between the invasiveness and the amount in the cells and the sera
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS