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FLASH GENE
Symbol NAALADL2 contributors: mct/npt - updated : 15-10-2020
HGNC name N-acetylated alpha-linked acidic dipeptidase-like 2
HGNC id 23219
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta, mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies ortholog to murine Naladl2
Homologene
FAMILY
  • biotin--protein ligase family
  • glutamate carboxypeptidase II family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm
    text
  • localized at the basal cell surface where it promotes adhesion to extracellular matrix proteins
  • basic FUNCTION
  • activating biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting proteins
  • peptidase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DUP3QD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significantly decreased in the tissues of patients with inflammatory bowel disease (IBD) and intestinal Behçet’s disease (BD) compared to those in control tissues
    tumoral     --over  
    in colon and prostate tumours when compared with benign tissue
    Susceptibility
  • to Kawasaki disease (KD)
  • to intestinal Behçet's disease
  • Variant & Polymorphism SNP
  • rs17531088 significantly associated to KS (Burgner 2009)
  • NAALADL2 gene locus (rs3914501),is associated with intestinal Behçet's disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS