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FLASH GENE
Symbol SFTPB contributors: mct/npt - updated : 19-05-2008
HGNC name surfactant protein B
HGNC id 10801
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratoryrespiratory tractbronchus   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryalveolar cell type 1
Respiratoryalveolar cell type II
Respiratoryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • N and C terminal peptides flanking the mature factor
  • an alternatively spliced in normal lung, saposin-like
  • N-terminal segment comprising residues 1-9, specifically required for surface activity, and prolines 2, 4, and 6 as well as tryptophan 9, may constitute essential structural motifs for protein function (Serrano 2006)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • structural integrity of pneumocytes and normal processing of surfactant complex
  • play an important role in surfactant metabolism and host defense mechanisms in the lung (Kim 2007)
  • absolutely required for the surface activity of pulmonary surfactant and postnatal lung function (Serrano 2006)
  • SFTPB, and SFTPC proteins promote the formation of proteolipid channels in which lipid molecules are functionally involved
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functional cooperation between surfactant proteins SFTPB and SFTPC may be required to sustain a proper compression-expansion dynamics in the presence of physiological proportions of cholesterol
  • cell & other
  • surfactant-associated glycoprotein
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SMDP1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in papillary thyroid carcinoma
    Susceptibility
  • to respiratory distress in premature infant associated with SFTPA polymorphism(s) and restricted to patients with the Y131Y SFTPB genotype
  • to idiopathic pulmonary fibrosis in smokers
  • Variant & Polymorphism SNP
  • T131I, B1580 C
  • VNTR in intron 4 is associated with an increased 60 day mortality in acute respiratory distress syndrome (Currier 2008)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS