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FLASH GENE
Symbol MED25 contributors: mct/npt/pgu - updated : 28-09-2011
HGNC name mediator complex subunit 25
HGNC id 28845
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunespleen   highly
Nervousbrain   highly
Reproductivefemale systemuteruscervix  
 female systemplacenta  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines prostate cancer(much lower level in metastatic cancer compared to that in primary prostate cancer)
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two conserved structural domains with limited similarity to domain D of synapsin I
  • an activator interaction domain (ACID), which forms a seven-stranded beta-barrel framed by three helices, and the VP16 subdomains H1 and H2 bind to opposite faces of ACID and cooperate during promoter-dependent activated transcription
  • a MED25 domain that serves as a docking site on Mediator for the ATF6 transcription activation domain
  • HOMOLOGY
    interspecies homolog to murine Med25 (93.0pc)
    Homologene
    FAMILY
  • mediator complex subunit 25 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • associating with the activation domains of multiple cellular and viral transcriptional activators, including the herpes simplex viral activator VP16, mammalian cells,
  • required for RARA/RXRA-mediated transcription
  • serving as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
  • potential role of MED25 in gene dosage sensitive peripheral neuropathy pathogenesis
  • MED25 and PTOV1 reciprocally regulate RAR transcriptional activity through competitive bindings to CREBBP and opposite regulation of CREBBP recruitment to the RA(Retinoic acid)-responsive gene promoter
  • MED25 and PTOV1 differentially modulate RA sensitivity in cancer cells depending on their expression levels
  • role for MED25 and the Mediator complex in the regulation of xenobiotic metabolism and lipid homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mediator complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CREBP, ESR1, GR, RARA, RXRA and THRB in a ligand-dependent manner
  • required for the association of HNF4A with Mediator, its several cofactors, and RNA Pol II
  • critical target of the potent herpes simplex 1 viral transcriptional activator VP16
  • regulatory interaction between SOX9, WWP2 and MED25 defines the SOX9 transcriptional mechanisms of chondrogenesis in the forming palate
  • MED1 and MED25, regulate a restricted cohort of genes that are predominantly not controlled by GATA1
  • ATF6-MED25 interaction contributes to Mediator recruitment to genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2B2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS