protein
| acute myeloid leukemia (AML) cells require the BRD9 subunit of the SWI-SNF chromatin-remodeling complex to sustain MYC transcription, rapid cell proliferation and a block in differentiation |
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BRD9 interacts with BRD4 in a bromodomain-dependent fashion, which leads to the recruitment of GBAF complexes to chromatin, explaining the functional similarity between these epigenetic regulators |
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BRD9 and BRG1 cooperate to regulate a subset of genes in ESCs that are critical for ESC maintenance |
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BICRA and BICRAL each exclusively associate with BRD9, but not with SMARCB1 (PMID; |
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BRD9 binds enhancer regions in a cell type-specific manner, regulating cell type-related processes |
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BRD9-STAT5 axis as critical for leukemia maintenance |
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the bromodomain of BRD9 binds acetylated K515 on ATRX and facilitates ATRX interaction with RAD51, which is essential for HR |