protein
| US11, a virally encoded ER protein |
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interacting with CFTR (recognizes misfolded, nonubiquitylated CFTR to initiate its dislocation and degradation early in the course of CFTR biogenesis, perhaps by detecting structural instability within the first transmembrane domain) |
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associates physically and functionally with BCAP31 in the CFTR DeltaF508 degradation pathway (Wang 2008) |
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SELK interacts with all three Derlins and has a higher affinity for DERL1 |
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DNAJB9 associate with the integral membrane protein, DERL1 |
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FAF2 and DERL1 bind with each other and with lipidated APOB and show colocalization around lipid droplets (LDs) |
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SOD1 (SOD1(WT)) comprises a masked DERL1 binding region, that, under zinc-deficient conditions, adopts a mutant-like conformation exposing the DBR and inducing the homeostatic ER stress response |
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CAV1 may be a cofactor in the interaction of DERL1 and PTGS2 and may facilitate DERL1- and VCP complex-mediated PTGS2 ubiquitination, retrotranslocation, and degradation |
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overexpressed USP19 interacts with DERL1 and other ERAD machinery factors in the membrane, but endogenous USP19 is mostly in the cytosol where it binds Hsp90 |
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DERL1 promotes SCNN1A ubiquitylation and enhances SCNN1A ubiquitin- mediated proteasome degradation |
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SOD1-DERL1 interaction contributes to the pathogenesis of ALS and is a promising drug target for ALS treatment |