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FLASH GENE
Symbol TTC17 contributors: mct - updated : 28-09-2021
HGNC name tetratricopeptide repeat domain 17
HGNC id 25596
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Lymphoid/Immunespleen    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tetratricopeptide repeat domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text
  • presence of TTC17 and CCDC157 on Golgi membranes
  • basic FUNCTION
  • TTC17 and CCDC157, localized along the secretory pathway and were found to interact with resident proteins of ER-Golgi membranes
  • TTC17 is required for the polarized arrangement of Golgi cisternae and posttranslational modifications
  • TTC17 and CCDC157, are new actors of critical importance for the structure and function of Golgi membranes
  • localizes outside the ciliary compartment and is involved in actin organization and pre-ciliogenesis (PMID;
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CATIP interact with TTC17, and CATIP-TTC17 axis would regulate actin polymerization and ciliogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS