basic FUNCTION
| having transcription factor activity |
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regulate podocyte gene expression during the development of nephrotic syndrome |
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ZHX2 contributes to AFP repression in the liver after birth and may also be involved in AFP reactivation in liver cancer |
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ZHX2 and ZHX3 were involved in the transcriptional repression of the hepatocellular cacinoma markers in normal hepatocytes, suggesting that the failure of the ZHX2 and/or ZHX3 expression might be a critical factor in the hepatocellular carcinogenesis |
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may participate in globin regulation and may be important in the normal physiology of erythrocytes |
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ZHX2 is a novel regulator of neural progenitor cell maintenance |
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acts as a transcriptional repressor in cell, and its repressor activity is enhanced by coexpression of an EFNB1 intracellular domain |
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functions as a novel developmental regulator of key genes influencing lipoprotein metabolism |
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ZHX2 promotes macrophage survival and proinflammatory functions in atherosclerotic lesions, thereby contributing to lesion growth |
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ZHX2 plays likely roles in the regulation of bipolar cell subset fate determination during retinal development |
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ZHX2 could inhibit proliferation and promote apoptosis of lung cancer cells by inhibiting MAPK14 signaling pathway |