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FLASH GENE
Symbol ZKSCAN4 contributors: mlc - updated : 24-11-2007
HGNC name zinc finger with KRAB and SCAN domains
HGNC id 13854
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunetonsils    
Nervousbrain   highly
Reproductivefemale systemuteruscervix  
 male systemtestis   
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text heart, brain, skeletal muscle, small intestine, and liver tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven C2H2-type zinc fingers
  • one KRAB domain
  • one SCAN box domain
  • an LER domain
    • HOMOLOGY
    Homologene
    FAMILY krüppel C2H2-type zinc-finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing TP53 degradation
  • transcriptional repressor that inhibits p53 and p21 transcriptional activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS