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FLASH GENE
Symbol CHCHD6 contributors: mct/shn - updated : 11-05-2014
HGNC name coiled-coil-helix-coiled-coil-helix domain containing 6
HGNC id 28184
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a coiled coil helix-coiled coil helix domain at its C-terminal
HOMOLOGY
interspecies ortholog to Chchd6, Mus musculus
ortholog to Chchd6, Rattus norvegicus
ortholog to CHCHD6, Pan troglodytes
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
text predominantly localizes to mitochondrial inner membrane
basic FUNCTION
  • regulation of mitochondrial cristae morphology, cell growth, ATP production, and oxygen consumption
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • IMMT and CHCHD6, which physically interact, are two components of the MICOS
  • CHCHD6, APOOL and APOO appear to be periphery subunits of the MICOS complex, because their depletion does not affect cristae morphology or stability of other components
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mitofilin, DISC1 and CHCHD3
  • IMMT and CHCHD6 directly interacted with SAMM50
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • CHCM1/CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology, and leads to reductions in cell growth, ATP production, and oxygen consumption