basic FUNCTION
| endogenous ligands for maintaining homeostasis after stress, and could allow the design of drugs to ameliorate stress-related diseases |
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involved in the control of myometrial contractility during pregnancy |
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in the brain it may be responsible for the effects of stress on appetite |
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might represent an endogenous ligand for maintaining homeostasis after stress |
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exert an anti-inflammatory effect via induction of macrophage apoptosis (through CRHR2 binding) |
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can suppress tumor growth predominantly by inhibition of tumor vascularization, but also potentially through direct effects on tumor cell proliferation |
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exerts potent beneficial effects in the cardiovascular system, including inhibition of apoptosis, improvement of cardiomyocyte contractility and decrease of oxidative stress (Bühler 2009) |
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hypoxia-mediated induction of UCN2 may help to preserve cardiac function and prevent apoptosis in ischaemic condition in the heart (Bühler 2009) |
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suppresses food intake, delays gastric emptying and decreases heat-induced edema |
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activates mitochondrial ATP-sensitive potassium channels and prevents the opening of the mitochondrial permeability transition pore |
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possible involvement of UCN2 and UCN3 in the mechanisms of endometriosis |
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potently suppressed feeding via a CRF-dependent mechanism without eliciting malaise |
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implicated in the regulation of AMPK activation in the heart |