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FLASH GENE
Symbol REL contributors: mct/ - updated : 12-09-2017
HGNC name v-rel reticuloendotheliosis viral oncogene homolog (avian)
HGNC id 9954
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  highly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • IPT/TIG domain with an immunoglobulin like fold
  • RHD domain
  • HOMOLOGY
    interspecies homolog to murine Rel
    intraspecies homolog to avian reticuloendotheliosis viral (v-rel) oncogene
    homolog to NF-kappa B enhancer binding protein,related
    Homologene
    FAMILY
  • NF-kappa B/Rel family of transcription factors
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • participates in the control of a wide array of genes, including genes involved in embryonic development and regulation of immune, inflammation, and stress responses
  • involved in lymphomagenesis (diffuse large B cell lymphoma)
  • may play a role in the pathogenesis of classic Hodgkin lymphoma
  • plays a critical role in regulating the innate inflammatory response to microflora within the lower bowel, likely through its ability to modulate expression of IL12/23 family members
  • necessary for long-term synaptic potentiation and hippocampus-dependent memory formation
  • important for both the thymic development and peripheral homeostatic proliferation of T reg cells
  • with NF-kappaB1 have differential roles in Treg development
  • plays an important role in the expression of IL21 in T cells and subsequently in IL21-dependent T(FH) cell development
  • IKBKB, IKBKG and REL control the levels of Claspin in the cells by an alternative mechanism to cell cycle
  • important function of IKBKB and REL in the DNA-damage response pathway
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the nuclear factor-kappaB (NF-kappaB) transcription factor
  • INTERACTION
    DNA binding to NF-kappa B enhancer
    RNA
    small molecule
    protein
  • interacting with CEBPB (enhances CEBPB binding to the C-reactive protein gene promoter)
  • interact directly with Ca(2+)-loaded calmodulin (can inhibit nuclear import of REL)
  • RBM39 is a new transcriptional coregulator for REL and reveals an important role in modulating REL oncogenic activity
  • REL and JUNB cooperatively regulate FOXP3 expression by modulating the chromatin architecture of FOXP3 promoter region
  • IRF4 activates IL2 and IL4 promoters in cooperation with REL
  • TNFSF13B signals coordinate both RELB and REL activities to ensure survival during peripheral B-cell maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with BCL11A in B cell lymphoma
    tumoral germinal mutation      
    S525P mutation contributes to the development of B-cell lymphomas by affecting an IKBKA-regulated transactivation activity of REL
    Susceptibility
  • to rheumatoid arthritis
  • to Hodgkin lymphoma
  • Variant & Polymorphism SNP
  • SNPs, rs13031237 and rs13017599 increasing the risk of rheumatoid arthritis
  • SNP increasing the risk of Hodgkin lymphoma
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS