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FLASH GENE
Symbol SECISBP2 contributors: mct/npt - updated : 26-02-2009
HGNC name SECIS binding protein 2
HGNC id 30972
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestine   
Endocrinethyroid   highly
Reproductivefemale systemuterus   
 male systemtestis  highly
 male systemprostate   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative RNA-binding domain
  • C-terminal domain involved in SECIS binding, ribosome binding and Sec incorporation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • is essential for the cotranslational insertion of sec into selenoproteins
  • may be involved in preventing termination at the UGA/sec codon
  • remains ribosome bound except during selenocysteine delivery to the ribosomal A-site
  • protein of the Sec incorporation machinery, having transcription and translation regulated in a coordinated manner in response to stress (Papp 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • EIF4A3 interaction with the selenoprotein mRNA prevents the binding of SECISBP2, which is required for selenocysteine insertion, thereby inhibiting the synthesis of the selenoprotein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THMD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS