basic FUNCTION
| having rhodopsin-like receptor activity |
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may be involved in G-protein coupled receptor protein signaling pathway |
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scavenger receptor for the SDF-1/CXCL12 |
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involved in pathobiologic process including cell growth, survival, adhesion, tumor growth (Burns 2006) |
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acting as a coreceptor with CXCR4 for a restricted number of HIV isolates |
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is involved in various biological processes such as the control of adhesion, mobility, angiogenesis and cell survival |
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greater expression of CXCR7 in term placenta as compared to early stages thus may be having a role in the vertical transmission of HIV1 (Tripathi 2009) |
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role on the adhesion, proliferation and angiogenesis of endothelial progenitor cells |
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plays an important role in human cord blood derived endothelial progenitor cells (EPCs) in response to CXCL12 |
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is essential for normal development, and promotes initiation and progression of diseases including cancer and autoimmunity |
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plays an important role on cell repair processing induced by CXCL12, and ACKR3 silencing attenuates cell adaptive response to acute CXCL12 stimulation after hypoxia |
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role in regulating the migration of plasmablasts during B-cell maturation |
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ACKR3 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells |
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is essential for the proper migration of interneuron precursors in the developing cerebral cortex |
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role for ACKR3 in oligodendrocyte progenitor cells (OPCs) maturation during remyelination and is a therapeutic strategy to promote remyelination in the adult central nervous system |