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FLASH GENE
Symbol BAHD1 contributors: mct/npt - updated : 14-11-2009
HGNC name bromo adjacent homology domain containing 1
HGNC id 29153
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal BAH domain, which is found in several chromatin-binding proteins involved in transcriptional repression and required for BAHD1 colocalization with H3K27me3 (Bierne 2009)
    • HOMOLOGY
    interspecies homolog to murine AW541238
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • heterochromatinization factor repressing several proliferation and survival genes, in particular the insulin-like growth factor II gene (IGF2)(Bierne 2009)
  • acts as a silencer by recruiting at specific promoters a set of proteins that coordinate heterochromatin assembly (Bierne 2009)
  • acts as a tumor suppressor through the silencing of cancer-related genes, such as IGF2, in adult tissues (Bierne 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with HP1, MBD1, HDAC5, and several transcription factors (acts as a silencer that connects heterochromatin factors, such as HP1, MBD1, and HDAC5, to DNA-bound transcription factors, such as SP1, to repress transcription at specific euchromatic loci)(Bierne 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in invasive lung cancer cells (Bierne 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS