basic FUNCTION
| playing a critical role for normal somitogenesis, and in the specification of the anterior somitic compartment |
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transcription factor activating gene transcription |
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playing a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways |
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also playing a role in the formation of epithelial somitic mesoderm and cardiac mesoderm |
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potentially responsible for the rostro-caudal patterning process itself in the anterior presomitic mesoderm, via cellular interaction |
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regulating the FGF signaling pathway |
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downregulating DLL1 in the presumptive rostral domain |
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acting as a suppressor of Notch activity |
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enhances the expression of the Notch1 receptor in the anterior presomitic mesoderm |
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final output signal by which the temporal information from the segmentation clock is translated into segmental patterning during mouse somitogenesis |