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FLASH GENE
Symbol MESP2 contributors: mct - updated : 10-10-2016
HGNC name mesoderm posterior 2 homolog (mouse)
HGNC id 29659
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text rostral presomitic mesoderm, but downregulated immediately after the formation of the segmented somites
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one bHLH domain
  • nuclear localization signals (NLS)
  • a degradation domain, which acts as a target of proteasome-mediated proteolysis and appears to play this role
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Mesp2
    intraspecies homolog to MESP1
    Homologene
    FAMILY
  • BHLH family of transcriptional regulatory proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a critical role for normal somitogenesis, and in the specification of the anterior somitic compartment
  • transcription factor activating gene transcription
  • playing a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways
  • also playing a role in the formation of epithelial somitic mesoderm and cardiac mesoderm
  • potentially responsible for the rostro-caudal patterning process itself in the anterior presomitic mesoderm, via cellular interaction
  • regulating the FGF signaling pathway
  • downregulating DLL1 in the presumptive rostral domain
  • acting as a suppressor of Notch activity
  • enhances the expression of the Notch1 receptor in the anterior presomitic mesoderm
  • final output signal by which the temporal information from the segmentation clock is translated into segmental patterning during mouse somitogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MESP1 (down-regulated in the later stages of development by the activities of MESP2 in the wild-type embryo)
  • RIPPLY2-MESP2 negative-feedback loop is essential for the periodic generation of the rostro-caudal polarity within a somite
  • potential interaction of MESP2 and TBX6 to cooperatively create periodic patterns coupled with the clock machinery
  • TBX6 controls the expression of MESP2, which encodes a basic helix-loop-helix transcription factor that has crucial roles in somitogenesis
  • RIPPLY2, a target of MESP2, is proposed to be involved in this down-regulation because RIPPLY2 deficiency causes an anterior expansion of the TBX6 domain, resembling the MESP2-null phenotype
  • cell & other
    REGULATION
    activated by TBX6 binding, mediating Notch signaling and subsequent transcription in the anterior presomitic mesoderm
    ASSOCIATED DISORDERS
    corresponding disease(s) SCDO2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    in Mesp2-null mice, complete disruption of somitogenesis, including segment border formation, rostro-caudal patterning and epithelialization of somitic mesoderm