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FLASH GENE
Symbol TDRD7 contributors: mct - updated : 26-10-2018
HGNC name tudor domain containing 7
HGNC id 29303
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly Homo sapiens
 brainhindbraincerebellum   Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
Reproductivemale systemtestis  predominantly Homo sapiens
Visualeye     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
Reproductivespermatocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three copies of the LOTUS domain (domain found in germline-specific proteins that are present in the nuage/polar granules of germ cells) in its extreme N-terminus
  • a TUDOR domain binding symmetric dimethyl arginines present on the germ cell-specific Piwi proteins, which form a particular clade of Argonaute proteins
  • C-terminal two tudor-like domains.
  • HOMOLOGY
    Homologene
    FAMILY tudor domain containing gene family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic,granule
    text
  • localizes to chromatoid bodies
  • basic FUNCTION
  • tandem tudor domain protein that is expressed in male germ cells and localizes to chromatoid bodies
  • essential for haploid spermatid development and with TDRD6, are key biogenesis processes of chromatoid bodies
  • TDRD7 and TDRD6 constitute a spermiogenic class of tudor family genes, which function in a sequential and nonredundant manner
  • TDRD7 and TDRD6, play key roles in the early ribonucleoprotein remodeling and later structural maintenance, respectively
  • essential for early spermatid differentiation and is a master regulator of the biogenesis of chromatoid bodies
  • essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis
  • TDRD5 and TDRD7, play key roles in facilitating the function of PIWIs by acting as scaffolds
  • TDRD5-TDRD7 are required for spermiogenesis
  • TDRD5, TDRD7, RNF17 proteins play distinct roles during male germ cell development
  • TDRD7 plays an essential role in the maturation of autophagosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with the N-terminal domain of PCTAIRE 2 (CDK17) through its C-terminal domain which contains two tudor-like domains, and is a physiological partner of CDK17 in terminally differentiated neurons
  • TDRD7 bind and stimulate the germline-specific DEAD-box RNA helicase DDX4
  • TDRD7 might directly bind to TBC1D20 mRNAs and downregulate its expression, which is a key regulator of autophagosome maturation, resulting in the disruption of autophagosome maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCC7 , CCNOA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    causing cataracts and glaucoma, which become severe with age
    Susceptibility to age-related cataract (ARC)
    Variant & Polymorphism other
  • rs10981985 G&
  • 8201;&
    8594;&
    8201;A variant within the TDRD7 gene may protect against cortical age-related cataract (ARC)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS