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FLASH GENE
Symbol MCTS1 contributors: mct - updated : 22-01-2011
HGNC name malignant T cell amplified sequence 1
HGNC id 23357
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunethymus    
Urinarybladder    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines highly in B-cell lymphoma, amplified in T-cell lymphoma and NHL
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PUA, RNA binding domain
  • HOMOLOGY
    interspecies ortholog to murine Mcts1
    ortholog to rattus mcts1
    intraspecies homolog to homolog to cyclin Ha protein-protein binding domain
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potential role in regulation of cell cycle
  • protects against apoptosis, maybe by enhancing AKT kinase activation
  • potential role in promoting lymphoid tumor development
  • accelerates TP53 degradation by means of the ubiquitin-dependent proteolysis
  • loss of TP53, with its overexpression synergistically promote chromosome instability and tumorigenicity
  • implicated in the interaction with the cap complex of the mRNA, through an RNA binding domain, named PUA
  • LGTN and MCTS1/DENR promote release of tRNA and mRNA from recycled 40S subunits
  • roles for Ligatin and the related interacting proteins MCTS1 and DENR in ribosome recycling and initiation, two linked stages of translation
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    suggested to be involved in human breast cancer
    tumoral     --over  
    in lymphomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target targeted suppression of this domain attenuates the malignant phenotype and is a potential target for therapeutic intervention in lymphomas
    SystemTypeDisorderPubmed
    cancerhemopathy 
    ANIMAL & CELL MODELS